• Cabozantinib Powder CAS 849217-68-1 Manufacturer
  • Cabozantinib Powder CAS 849217-68-1 Manufacturer
  • Cabozantinib Powder CAS 849217-68-1 Manufacturer
  • Cabozantinib Powder CAS 849217-68-1 Manufacturer
  • Cabozantinib Powder CAS 849217-68-1 Manufacturer

Cabozantinib Powder CAS 849217-68-1 Manufacturer

CAS No.: 849217-68-1
Formula: C28h24fn3o5
Environmental Protection: Yes
Certification: REACH
Color: White
Appearance: Powder
Samples:
US$ 1/Kg 1 Kg(Min.Order)
| Request Sample
Gold Member Since 2022

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Rating: 5.0/5
Trading Company

Basic Info.

Model NO.
849217-68-1
We Can Ship
25-500kg to Europe
Payment Method
Btc, T/T, Western Union
Express
Safe Customs Clearance, We Have a Professional Cus
Export Market
Global (Safe Clearance)
Purity
High Purity
Delivery Time
1-3 Days
Arrival Time
12-15days( Safe Customs Clearance)
Transport Package
Bag/Bottle/Bucket
Specification
1KG
Trademark
harvest chemical
Origin
Wuhan
Production Capacity
50000kg

Product Description

Cabozantinib Powder CAS 849217-68-1 Manufacturer
 
Cabozantinib Powder CAS 849217-68-1 Manufacturer

Product Description
Product Name: Cabozantinib
Synonyms: Carbozantinib;Cabozantinib(XL184Malate);Cabozantinib (XL184, BMS-907351);N-(4-(6,7-diMethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide(CAS:849217-68-1);XL-186;1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide Cabozantinib (XL184, BMS-907351);Cabozantinib, >=98%
CAS: 849217-68-1
MF: C28H24FN3O5
MW: 501.51
EINECS: 692-846-8
Product Categories: Inhibitors;API

Cabozantinib  Description

Cabozantinib was approved inNovember 2012 for the treatment of patients with progressive, unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). Cabozantinib was granted orphan drug status by the FDA to facilitate development of newtreatment options for patients with MTC. It is a member of a class of tyrosine kinase inhibitors (TKIs) with nanomolar pan-inhibitory activity against VE-GFR2, MET, and RET among others. Inhibition of the VE-GF pathway has been shown preclinically to initially slow tumor growth, but rapid revascularization is followed by aggressive tumor growth. The MET pathway has been implicated in the development of VE-GF resistance, so dual VE-GF/MET activity is viewed as desirable. In addition, mutations in RET play a particular role in MTC, with 25% of the tumors inheriting a germlinemutation in the proto-oncogene, so multiple tyrosine kinase inhibition may be viewed as particularly beneficial for the treatment of MTC.


Cabozantinib  Uses

Cabozantinib (XL184, BMS-907351) is a potent VE-GFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively


Cabozantinib  Definition

 dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-t rosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
 
Contact:
WA:+86131=2991=5771
 
1. I want to know more details about the product, how can I contact you?
You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.
 
2. How do I know if your products are real or fake?
We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.
 
3. How do you ensure the safety of the package I receive?
I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.
 
4. How to pay?
Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.
 
5. How long does it take to receive the package?
This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.

Cabozantinib Powder CAS 849217-68-1 ManufacturerCabozantinib Powder CAS 849217-68-1 Manufacturer
Cabozantinib Powder CAS 849217-68-1 Manufacturer
Cabozantinib Powder CAS 849217-68-1 ManufacturerCabozantinib Powder CAS 849217-68-1 ManufacturerCabozantinib Powder CAS 849217-68-1 ManufacturerCabozantinib Powder CAS 849217-68-1 Manufacturer

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Gold Member Since 2022

Suppliers with verified business licenses

Rating: 5.0/5
Trading Company
Number of Employees
9
Year of Establishment
2019-03-27